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Table 1 Demographic characteristics of the clinical cohort

From: Synaptic biomarkers in the cerebrospinal fluid associate differentially with classical neuronal biomarkers in patients with Alzheimer’s disease and frontotemporal dementia

  

Diagnostic groups

Demographic characteristics

AD

FTD

SCD

ANOVA

P-value

Adjusted P-value

SCD vs FTD

Adjusted P-value

SCD vs AD

Adjusted P-value

AD vs FTD

n

20

20

20

-

-

-

-

Age

66 (58, 75)

64 (61, 68)

55 (51, 66)

0.02

ns

0.030

ns

Sex, female

10 (50%)

10 (50%)

5 (25%)

ns

ns

ns

ns

MMSE

21 (11, 25)

21 (17, 26)

29 (27, 30)

 < 0.001

 < 0.001

 < 0.001

ns

Aβ42

494 (443, 604)

846 (723, 1087)

1036 (870, 1101)

 < 0.001

ns

 < 0.001

 < 0.001

Tau

613 (516, 980)

385 (265, 482)

190 (159, 234)

 < 0.001

0.003

 < 0.001

0.015

PTau

83 (61, 111)

45 (38, 66)

35 (26, 42)

 < 0.001

0.014

 < 0.001

0.006

NfL

899 (702, 1160)

1880 (1495, 3346)

409 (292, 578)

 < 0.001

 < 0.001

0.006

0.006

  1. Demographic characteristics of patients. The data for sample size is presented as n (%) or as median (interquartile range). Age is shown in years and the fluid biomarker values are as pg/mL. P-values were calculated using Kruskal–Wallis’ one-way ANOVA and post hoc Dunn’s multiple comparisons. ns, not significant. This table has been previously published as part of a different project [25]