Fig. 3

Receiver-operating characteristic (ROC) analyses results of models using both (light blue), either (dark green and red), and none (yellow) of the (baseline model) baseline structural MRI and plasma measurements in the Aβ− CN and Aβ− MCI subgroups. Subplots that have less than four lines indicate the corresponding final model did not select both the baseline structural MRI and plasma measurements. Abbreviations: MCI, mild cognitive impairment; CDR-SOB, Clinical Dementia Rating Sum-of-Boxes; BA35, Brodmann area 35; AUC, area under the curve; ADNI-MEM, ADNI summary memory scores. ¹Since the CDR-SOB longitudinal change in most of the Aβ− CN subjects (108 out of 161) is equal to 0.0 /year, performing linear mixed effect modeling is not appropriate