APOE ε4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly

Table 3 Regional ¹¹C-PK11195 DVR values for APOE ε4 homozygotes, heterozygotes, and non-carriers

Region	¹¹C-PK11195 binding (DVR, partial volume effect corrected)				ε4ε4 vs ε3ε3	ε4ε4 vs ε4ε3	ε4ε3 vs ε3ε3
Region	*APOEε4ε4*	*APOEε4ε3*	*APOEε3ε3*	P_a	P_b	P_b	P_b
Prefrontal cortex	1.25 (0.086)	1.24 (0.086)	1.21 (0.087)	0.27	0.24	0.86	0.45
Parietal cortex	1.49 (0.13)	1.49 (0.11)	1.47 (0.13)	0.89	0.91	0.99	0.90
Anterior cingulum	1.11 (0.099)	1.11 (0.079)	1.12 (0.106)	0.87	0.86	0.96	0.96
Posterior cingulum	1.36 (0.13)	1.34 (0.081)	1.35 (0.079)	0.73	0.92	0.71	0.93
Precuneus	1.42 (0.13)	1.40 (0.12)	1.43 (0.095)	0.40	0.97	0.81	0.67
Lateral temporal cortex	1.26 (0.082)	1.29 (0.052)	1.24 (0.060)	0.08	0.71	0.31	0.07
Cortical composite	1.34 (0.77)	1.33 (0.052)	1.31 (0.058)	0.30	0.32	0.97	0.42
Transentorhinal, Braak I–II	1.09 (0.088)	1.08 (0.068)	1.10 (0.073)	0.79	0.93	0.96	0.80
Limbic, Braak III–IV	1.27 (0.070)	1.28 (0.048)	1.26 (0.052)	0.75	0.90	0.97	0.79

Data presented as mean (standard deviation)
P_a, one-way ANOVA; P_b, Tukey’s honest significance test for pairwise comparisons

ISSN: 1758-9193