Table 1 Demographics and descriptive data for cognitively unimpaired APOE ε4 homozygotes, heterozygotes, and non-carriers included in the study

Age (years), mean (SD)

67.3 (4.74)

67.3 (4.90)

68.3 (4.55)

0.75

Sex (M/F), n (%)

7/12 (37/63)

7/14 (33/67)

8/12 (40/60)

0.91

Education, n (%)

0.37

Primary school

7 (37)

4 (19)

7 (35)

Middle or comprehensive school

4 (21)

4 (19)

3 (15)

High school

7 (37)

6 (29)

7 (35)

College or university

1 (5)

7 (33)

3 (15)

BMI (kg/m²), mean (SD)

26.6 (4.48)

26.7 (3.46)

27.3 (4.96)

0.86

CERAD total score, mean (SD)

84.4 (9.43)

85.9 (7.98)

86.0 (7.42)

0.79

MMSE, median (IQR)

28 (27–29)

29 (28–30)^a

29 (27–30)

0.040

Total leukocyte count (E9/L), mean (SD)

5.38 (1.20)

5.70 (1.68)

5.22 (0.87)

0.49

¹¹C-PIB positivity, n (%)

16 (84)

10 (48)

8 (40)

0.0084

Computed Fazekas score, median (IQR)

1.09 (0.98)

0.92 (0.62)

0.82 (0.79)

0.80

¹¹C-PIB composite SUVR, median (IQR)

2.13 (1.61–2.83)

1.55 (1.43–2.02)

1.47 (1.38–1.66)^a

0.0024

¹¹C-PK11195 composite DVR, mean (SD)

1.34 (0.77)

1.33 (0.052)

1.31 (0.058)

0.30