Fig. 5
Comparison of PET and blood biomarkers of Aβ deposition and glial reactivity and their association with cognitive performance and brain structure. Higher cortical composite 11C-PiB-binding (A) but not plasma Aβ1-42/1–40 (B) was associated with lower entorhinal volumes and lower scores in the Alzheimer’s Prevention Initiatives preclinical cognitive composite (APCC) battery. C Cortical composite 11C-PK11195 PET was associated only with lower hippocampal and entorhinal volume, whereas D elevated plasma GFAP levels were associated with lower APCC and Mini Mental State Examination (MMSE) scores. The results are shown as standardized estimates (betas) derived from liner models adjusted for age, sex, and education (and used MRI scanner for structural variables). CERADTS, Consortium to Establish a Registry for Alzheimer’s Disease total score; VT, total volume