Fig. 3
Regional association between amyloid PET and TSPO PET in cognitively unimpaired volunteers stratified by APOE ε4 gene dose. A Scatterplots from ROI level data showed positive correlation (Spearman’s rank correlation) for APOE ε4 carriers in cortical and Braak III–IV composite regions, whereas negative associations were present for non-carriers. B Most significant voxel-wise positive correlations between 11C-PiB and 11C-PK11195-binding were present in the APOE ε4/ε3 heterozygotes (yellow scale) and in APOE ε4 homozygotes (red scale), whereas only sparse significant voxels were seen in non-carriers (green scale). Partial volume corrected 11C-PiB SUVR and.11C-PK11195 BPND images smoothed using Gaussian 8 mm FWHM filter were used for all voxel-wise analysis. False Discovery Rate corrected cluster level threshold was set at P < 0.05