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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: APOE ε4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly

Fig. 1

Study flowchart. Altogether 60 individuals were recruited based on their APOE ε4 gene dose (APOE ε4/ε4, n = 19, APOE ε4/ε3, n = 21, APOE ε3/ε3 n = 21). All underwent positron emission tomography (PET) imaging targeting Aβ using 11C-PiB, 18-kDa translocator protein (TSPO) as a proxy for glial reactivity using.11C-PK11195, magnetic resonance imaging (MRI), and cognitive testing. A blood sample was drawn for laboratory measurements, including plasma markers of Aβ pathology (Aβ1-40 and Aβ1-42) and reactive astrocytosis (glial fibrillary acidic protein, GFAP)

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