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Fig. 6 | Alzheimer's Research & Therapy

Fig. 6

From: Association of cortical and subcortical microstructure with disease severity: impact on cognitive decline and language impairments in frontotemporal lobar degeneration

Fig. 6

Correlations of subcortical fractional anisotropy and subcortical mean diffusivity with VFT and BNT scores. Correlations of subcortical fractional anisotropy (left) and subcortical mean diffusivity (right) with VFT and BNT scores in each FTLD subgroup. Top: Regions of lower fractional anisotropy associated with higher VFT scores (blue-light blue) were found in the nfvPPA patients, whereas regions of increases in mean diffusivity related to increases in VFT scores (red–orange) were found in the bvFTD and nfvPPA patients. Bottom: Regions of lower fractional anisotropy associated with higher BNT scores (bluelight–blue) were found in the bvFTD patients, whereas regions of increases in mean diffusivity related to increases in VFT scores (red–orange) were found in the bvFTD and nfvPPA patients. The results have been overlaid on a skull-stripped MNI152 template. bvFTD, behavioral variant of frontotemporal dementia; BNT, boston naming test; FTLD, frontotemporal lobar degeneration; nfvPPA, nonfluent variant primary progressive aphasia; svPPA, semantic variant primary progressive aphasia; VFT, verbal fluency test

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