Fig. 3

Relationship between cortical thickness and cortical mean diffusivity with CDR® plus NACC FTLD-SB scores. Correlations of cortical thickness (top) and cortical mean diffusivity (bottom) with the CDR® plus NACC FTLD-SB scores in each FTLD subgroup. Small regions of cortical thinning associated with higher CDR® plus NACC FTLD-SB scores (light blue–blue) were found in the bvFTD, nfvPPA, and svPPA patients, whereas extensive areas of increased cortical mean diffusivity related to increases in CDR® plus NACC FTLD-SB scores (orange–red) were found in each subgroup. Only the clusters that survived familywise error correction P < 0.05 are shown. bvFTD, behavioral variant of frontotemporal dementia; CDR® plus NACC FTLD-SB, clinical dementia rating plus national Alzheimer’s coordinating center behavior and language domains sum of boxes; FTLD, frontotemporal lobar degeneration; nfvPPA, nonfluent variant primary progressive aphasia; svPPA, semantic variant primary progressive aphasia