Table 2 Mixed-effects model results for APOE genetic status and CR in relationship to cognitive trajectories (N=1819)

Time

− 0.002 (− 0.017, 0.013)

0.76

-

0.028 (0.009, 0.047)

0.004 **

-

− 0.023 (− 0.039, − 0.008)

0.003 **

-

Time²

− 0.004 (− 0.004, − 0.004)

< 0.001 ***

-

− 0.003 (− 0.003, − 0.002)

< 0.001 ***

-

− 0.004 (− 0.005, − 0.004)

< 0.001 ***

-

CR index

0.381 (0.330, 0.432)

< 0.001 ***

0.43

0.327 (0.268, 0.386)

< 0.001 ***

0.38

0.356 (0.300, 0.411)

< 0.001 ***

0.42

APOE-ε2

− 0.015 (− 0.117, 0.087)

0.77

0.02

− 0.029 (− 0.146, 0.088)

0.63

0.03

− 0.039 (− 0.150, 0.072)

0.49

0.05

APOE-ε4

− 0.012 (− 0.085, 0.061)

0.74

0.01

− 0.002 (− 0.085, 0.081)

0.96

0.00

− 0.028 (− 0.107, 0.050)

0.48

0.03

CR index × time

0.002 (− 0.005, 0.009)

0.53

0.03

0.003 (− 0.004, 0.011)

0.39

0.05

− 0.001 (− 0.007, 0.005)

0.83

0.01

APOE-ε2 × time

0.005 (− 0.008, 0.018)

0.46

0.07

0.003 (− 0.012, 0.017)

0.71

0.04

0.004 (− 0.007, 0.016)

0.47

0.07

APOE-ε4 × time

− 0.022 (− 0.031, − 0.012)

< 0.001 ***

0.30

− 0.024 (− 0.035, − 0.014)

< 0.001 ***

0.33

− 0.014 (− 0.023, − 0.006)

< 0.001 ***

0.24

CR index × APOE-ε2

− 0.007 (− 0.136, 0.123)

0.92

0.01

0.012 (− 0.136, 0.159)

0.88

0.01

− 0.020 (− 0.160, 0.120)

0.78

0.02

CR index × APOE-ε4

− 0.096 (− 0.185, − 0.008)

0.03 *

0.11

− 0.052 (− 0.153, 0.049)

0.31

0.06

− 0.086 (− 0.182, 0.009)

0.08

0.10

CR index × APOE-ε2 × time

0.008 (− 0.008, 0.024)

0.33

0.11

0.011 (− 0.007, 0.030)

0.22

0.16

0.008 (− 0.007, 0.022)

0.30

0.12

CR index × APOE-ε4 × time

0.012 (0.000, 0.023)

0.04 *

0.16

0.016 (0.003, 0.029)

0.01 *

0.22

0.007 (− 0.003, 0.017)

0.16

0.12