Fig. 3
Estimates of longitudinal cognitive change based on AD-PRSw/oAPOE and level of cognitive reserve. Estimated cognitive change (95% CI) shown for high vs. low AD-PRSw/oAPOE and high vs. low CR index scores, represented by the 25th and 75th percentiles for illustration purposes. Sample means were used in the estimation of all other covariates. Cognitive change is shown separately for global (top), memory (middle), and executive function (bottom) factor scores based on the full models, as shown in Table 3. The AD-PRSw/oAPOE × time interactions were significant for the global and executive function factor scores, but not for the memory factor score