Uncovering heterogeneous cognitive trajectories in mild cognitive impairment: a data-driven approach

Wang, Xiwu; Ye, Teng; Zhou, Wenjun; Zhang, Jie

doi:10.1186/s13195-023-01205-w

Alzheimer's Research & Therapy

Table 2 Summary of linear mixed-effects models

From: Uncovering heterogeneous cognitive trajectories in mild cognitive impairment: a data-driven approach

	MMSE			Memory composite score			Executive function composite score
Predictors	Coefficients	SE	p value	Coefficients	SE	p value	Coefficients	SE	p value
Age × time	0.0011	0.0027	0.6819	-0.0020	0.0005	< 0.0001	-0.0001	0.0007	0.9233
Female gender × time	-0.0025	0.0386	0.5208	-0.0180	0.0067	0.0075	-0.0142	0.0100	0.1554
Education × time	-0.0074	0.0068	0.2791	-0.0029	0.0012	0.0131	-0.0065	0.0018	0.0003
APOE4 carriers × time	-0.1399	0.0389	0.0003	-0.0297	0.0068	< 0.0001	-0.0130	0.0100	0.1959
Mild decliners × time	-0.3193	0.0465	< 0.0001	-0.0865	0.0081	< 0.0001	-0.1084	0.0120	< 0.0001
Moderate decliners × time	-1.2590	0.0536	< 0.0001	-0.2103	0.0093	< 0.0001	-0.2905	0.0138	< 0.0001
Aggressive decliners × time	-3.1750	0.0832	< 0.0001	-0.3877	0.0145	< 0.0001	-0.4563	0.0228	< 0.0001
	aVV			aEV			aHV
Predictors	Coefficients	SE	p value	Coefficients	SE	p value	Coefficients	SE	p value
Age × time	0.0104	0.0033	0.0017	-0.0015	0.0004	0.0006	-0.0013	0.0003	< 0.0001
Female gender × time	-0.0698	0.0476	0.1430	-0.0049	0.0060	0.4102	-0.0228	0.0041	< 0.0001
Education × time	0.0214	0.0082	0.0093	-0.0022	0.0010	0.0319	-0.0007	0.0007	0.3294
APOE4 carriers × time	0.3513	0.0468	< 0.0001	-0.0216	0.0058	0.0002	-0.0248	0.0040	< 0.0001
Mild decliners × time	0.5588	0.0569	< 0.0001	-0.0260	0.0070	0.0002	-0.0301	0.0049	< 0.0001
Moderate decliners × time	1.2790	0.0637	< 0.0001	-0.0759	0.0081	< 0.0001	-0.0859	0.0057	< 0.0001
Aggressive decliners × time	2.7090	0.1011	< 0.0001	-0.0704	0.0122	< 0.0001	-0.0977	0.0086	< 0.0001
	FDG SUVRs			AV45 SUVRs			CSF Aβ42
Predictors	Coefficients	SE	p value	Coefficients	SE	p value	Coefficients	SE	p value
Age × time	0.0001	0.0001	0.3708	-0.0000	0.0002	0.9945	-0.0833	0.0579	0.151
Female gender × time	-0.0019	0.0014	0.1760	0.0013	0.0026	0.6208	-0.2765	0.8175	0.735
Education × time	-0.0003	0.0002	0.1579	0.0009	0.0005	0.0748	-0.0749	0.1469	0.610
APOE4 carriers × time	-0.0030	0.0014	0.0297	0.0104	0.0027	0.0001	1.1217	0.8007	0.162
Mild decliners × time	-0.0068	0.0018	0.0001	0.0029	0.0030	0.3265	0.3555	1.0177	0.727
Moderate decliners × time	-0.0178	0.0018	< 0.0001	-0.0061	0.0041	0.1342	-0.0674	1.0562	0.949
Aggressive decliners × time	-0.0199	0.0030	< 0.0001	-0.0133	0.0063	0.0351	-0.0975	1.6161	0.952
	CSF t-tau			CSF p-tau				\
Predictors	Coefficients	SE	p value	Coefficients	SE	p value	\	\	\
Age × time	-0.0441	0.0754	0.5593	-0.0794	0.0584	0.1746	\	\	\
Female gender × time	1.0084	1.0639	0.3437	-0.2223	0.8223	0.7870	\	\	\
Education × time	0.4866	0.1919	0.0115	0.0218	0.1480	0.8831	\	\	\
APOE4 carriers × time	-1.0515	1.0448	0.3147	-0.7189	0.8105	0.3755	\	\	\
Mild decliners × time	1.0575	1.3234	0.4246	-0.5903	1.0249	0.5649	\	\	\
Moderate decliners × time	2.6670	1.3778	0.0535	-0.5745	1.0674	0.5906	\	\	\
Aggressive decliners × time	4.3979	2.1002	0.0367	0.6619	1.6368	0.6861	\	\	\

Notes: The main effects of predictors (i.e., age, gender, years of education, APOE4 status, cluster membership, and years since baseline) are included in all models, while coefficients are not shown for the sake of brevity. Coefficients are unstandardized values, which represent the magnitude of change in each AD biomarker yearly
Abbreviations: MMSE Mini-Mental State Examination, aVV adjusted ventricular volume, aEV adjusted entorhinal cortex volume, aHV adjusted hippocampal volume, FDG fludeoxyglucose, SUVRs standardized uptake value ratios, AV45 florbetapir, Aß42 ß-amyloid, t-tau total tau, p-tau phosphorylated tau

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ISSN: 1758-9193

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