Fig. 6
PTH1-34 reduction of serum inflammatory cytokines. A Representative images of serum L-Series label-multiplex antibody arrays of 6 ~ MO WT and 5XFAD female mice with PTH1-34 or Veh treatment. Proteins with changes are marked by dashed blue circles. B Total quantification analyses of the data in A. WT-Veh group were normalized to 1, n = 36 proteins per group. C Quantification of relative serum protein levels in A. The data showed those proteins that were significantly changed and arranged into different groups according to their characteristics. The data were presented as mean ± SD (n = 4 mice per group), *P < 0.05, **P < 0.01, ***P < 0.001, one-way ANOVA with Tukey’s multiple-comparison test. D Heat map of serum protein. n = 4, significant difference was set at P < 0.05. E Comparison of the PTH1-34 downregulated cytokines in serum of 5XFAD mice (downregulated cytokines in serum of PTH1-34 treated 5XFAD mice over 5XFAD control mice) to those detected in the cortex or hippocampus of 5XFAD-PTH1-34 mice. F Comparison between the 5XFAD with Tg2576 antibody array of secreted proteins in serum