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Fig. 7 | Alzheimer's Research & Therapy

Fig. 7

From: Clusters of co-abundant proteins in the brain cortex associated with fronto-temporal lobar degeneration

Fig. 7

Cell type enrichment of the modules with (non-)validated protein abundance patterns. A, B The proteins in the modules that were validated were analysed for enrichment of known cell type markers (see the “Materials and methods” section). “Up” (red) indicates that the markers for that specific cell type had high log2FC values in the tau cohort compared to NHC, suggesting enrichment of these cell types in the tau subjects. “Down” (blue) indicates that the markers for that specific cell type had low log2FC values in the tau cohort compared to NHC, suggesting depletion of these cell types in the tau subjects. This analysis was performed both on the modules validated in the frontal samples (A) and on the modules validated in the temporal samples (B) of the validation set. C, D The same procedure was performed on the modules where we were not able to validate the protein abundance patterns

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