Fig. 5

The mean differential protein abundance levels of the 17 co-regulated modules. The mean log2 fold change (log2FC) protein abundance levels for each module are provided in the table. Red indicates an upregulated mean log2FC protein abundance level within the module compared to NHC, and blue indicates a downregulated mean log2FC protein abundance level within the module compared to NHC. A bold font indicates that the mean log2FC was significantly different from zero (corrected p < 0.05). Additionally, the sizes of the modules and most significant subnetworks are provided. M0 is not a module but consists of the leftover proteins that do not fit in any of the 17 modules (M1 to M17). One asterisk next to a module name indicates that protein abundance patterns with the module were validated in one of the validation data sets, and two asterisks indicate that module protein abundance patterns were validated in both validation data sets. More detail about the module validation can be found in Table S2