Fig. 2

Volcano plot of pairwise proteome comparisons. Distribution of the log2 fold change (log2FC) protein abundance level (x-axis) and corresponding p-value (y-axis) for the proteome comparison between A FTLD-tau and NHC, B FTLD-tau and FTLD-TDP, and C FTLD-TDP and NHC. Levels of significance are indicated by the blue colour: the darker the colour, the more significant the contrast, with corresponding false discovery rates (FDR) indicated in the legend. The most highly and significantly dysregulated proteins are indicated by their names. SLC4A7, solute carrier family 4 member 7; FABP7, fatty acid-binding protein 7; ANXA1, Anexin 1; GFAP, glial fibrillary acid protein; TNC, Tenascin C; PDHA1, pyruvate dehydrogenase E1 subunit alpha 1; IDH3B, isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta; ANKRD29, ankyrin repeat domain 29; HSDL2, hydroxysteroid dehydrogenase like 2; PAFAH1B3, platelet-activating factor acetylhydrolase IB subunit alpha1