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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Cerebral Aβ deposition precedes reduced cerebrospinal fluid and serum Aβ42/Aβ40 ratios in the AppNL−F/NL−F knock-in mouse model of Alzheimer’s disease

Fig. 2

Cerebral Aβ plaque burden in AppNL−F/NL−F knock-in mice. Cerebral Aβ42 immunoreactivity and thioflavin S-positive fibrillar dense-core plaques were measured in 3 (n = 9)-, 6 (n = 7)-, 9 (n = 8)-, 12 (n = 7)-, 16 (n = 8)-, and 18 (n = 9)-month-old AppNL−F/NL−F knock-in mice. Minor initial deposition of extracellular Aβ plaques in cortical brain regions was observed from 6 months of age. The burden of cortical and hippocampal A Aβ42 immunoreactivity and B thioflavin S-positive fibrillar dense-core plaques was significantly increased in an age-dependent manner. Data is presented as median and IQR. Whiskers represent data within 1.5IQR of the lower and upper quartiles. For comparison between groups, statistical analyses were performed using the Kruskal–Wallis H test followed by the Mann–Whitney U test for post hoc group comparisons. Scale bars: 500 μm. Abbreviations: Aβ, amyloid beta; IQR, interquartile range

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