Skip to main content
Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Cerebral Aβ deposition precedes reduced cerebrospinal fluid and serum Aβ42/Aβ40 ratios in the AppNL−F/NL−F knock-in mouse model of Alzheimer’s disease

Fig. 1

CSF and serum Aβ42/Aβ40 ratios in AppNL−F/NL−F knock-in mice. CSF and serum Aβ42/Aβ40 ratios were measured in 3 (n = 9)-, 6 (n = 7)-, 9 (n = 8)-, 12 (n = 7)-, 16 (n = 8)-, and 18 (n = 9)-month-old AppNL−F/NL−F knock-in mice. A The Aβ42/Aβ40 ratio in CSF showed a significant reduction from 12 months of age while B the  Aβ42/Aβ40 ratio in serum was significantly declined from 16 months of age. C The Aβ42/Aβ40 ratio in serum correlated significantly positive with the corresponding ratio in CSF. Data is presented as median and IQR. Whiskers represent data within 1.5IQR of the lower and upper quartiles. For comparison between groups, statistical analyses were performed using the Kruskal–Wallis H test followed by the Mann–Whitney U test for post hoc group comparisons (*p < 0.05, **p < 0.01, ***p < 0.001). Correlation analysis was performed using Spearman’s rank-ordered correlation coefficient. Abbreviations: Aβ, amyloid beta; CSF, cerebrospinal fluid; IQR, interquartile range

Back to article page