Table 3 Sensitivity analyses of risk for dementia in the RLS and control groups
From: Restless leg syndrome and risk of all-cause dementia: a nationwide retrospective cohort study
Model 1: Definition of dementia by ICD-10 codes plus anti-dementia medicationsb | Model 2: Definition of RLS by ICD-10 code plus dopamine agonistsc | Model 3: Exclusion of patients taking antipsychotic agentsd | Model 4: Diagnosis of RLS by psychiatrists or neurologists | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cases, n (%) | aHRa (95% CI) | p-value | Cases, n (%) | aHRa (95% CI) | p-value | Cases, n (%) | aHRa (95% CI) | p-value | Cases, n (%) | aHRa (95% CI) | p-value | |
All-cause dementia | ||||||||||||
RLS group | 147 (6.2) | 1.51 (1.22–1.88) | < 0.001 | 129 (8.8) | 1.40 (1.12–1.76) | 0.004 | 256 (10.3) | 1.44 (1.22–1.70) | < 0.001 | 152 (13.2) | 1.86 (1.50–2.31) | < 0.001 |
Control group | 332 (3.4) | 1 (reference) | 316 (5.5) | 1 (reference) | 611 (6.2) | 1 (reference) | 316 (6.9) | 1 (reference) | ||||
AD | ||||||||||||
RLS group | 94 (3.9) | 1.23 (0.94–1.62) | 0.133 | 66 (4.5) | 1.36 (0.94–1.85) | 0.055 | 137 (5.5) | 1.37 (1.10–1.71) | 0.006 | 87 (7.5) | 1.76 (1.32–2.34) | < 0.001 |
Control group | 236 (2.4) | 1 (reference) | 162 (2.8) | 1 (reference) | 334 (3.4) | 1 (reference) | 176 (3.8) | 1 (reference) | ||||
VaD | ||||||||||||
RLS group | 45 (1.9) | 2.33 (1.58–3.43) | < 0.001 | 30 (2.1) | 1.62 (1.01–2.58) | 0.045 | 63 (2.5) | 1.79 (1.28–2.50) | 0.001 | 37 (3.2) | 2.72 (1.76–4.20) | < 0.001 |
Control group | 78 (0.8) | 1 (reference) | 68 (1.2) | 1 (reference) | 130 (1.3) | 1 (reference) | 58 (1.3) | 1 (reference) | ||||