Table 1 Characteristics of the study population
From: Restless leg syndrome and risk of all-cause dementia: a nationwide retrospective cohort study
Control group (n = 9977) | RLS group (n = 2501) | p-valuea | |
|---|---|---|---|
Age at enrollment (years) | 73.35 ± 5.18 | 73.40 ± 5.25 | 0.839 |
Sex | 0.936 | ||
Male | 3474 (34.8) | 873 (34.9) | |
Female | 6503 (65.2) | 1628 (65.1) | |
Income level by insurance fee | 0.213 | ||
Bottom 0 to 20th percentile | 2189 (21.9) | 520 (20.8) | |
Bottom 20th to 100th percentile | 7788 (78.1) | 1981 (79.2) | |
Region of residence | 0.368 | ||
Urban | 4092 (41.0) | 1001 (40.0) | |
Rural | 5885 (59.0) | 1500 (60.0) | |
CCI score | 1.22 ± 1.41 | 1.91 ± 1.75 | < 0.001 |
Comorbidities | |||
Schizophrenia or other psychotic disorder | 19 (0.2) | 20 (0.8) | < 0.001 |
Mood disorder | 434 (4.4) | 368 (14.7) | < 0.001 |
Anxiety disorder | 636 (6.4) | 412 (16.5) | < 0.001 |
Parkinson’s disease | 38 (0.4) | 115 (4.6) | < 0.001 |
Iron deficiency anemia | 165 (1.7) | 71 (2.8) | < 0.001 |
Sleep disorderb | 361 (3.6) | 316 (12.6) | < 0.001 |
Incidence of dementia | |||
All-cause dementia | 614 (6.2) | 260 (10.4) | < 0.001 |
AD | 336 (3.4) | 139 (5.6) | < 0.001 |
VaD | 130 (1.3) | 64 (2.6) | < 0.001 |
All-cause mortality | 490 (4.9) | 120 (4.8) | 0.814 |
Follow-up duration (years) | 3.94 ± 1.62 | 3.88 ± 1.60 | 0.068 |