Table 1 Plasmaboost cohort characteristics (n = 184)

APOE ε4, No. (%)

24 (33)^b

9 (28)

0 (0)

4 (13)

4 (11)

0.045

0.014

Female, no. (%)

36 (49)

16 (50)

7 (58)

10 (32)

19 (53)

0.89

0.20

Age, y

71 (68–76)

69 (64–77)

69 (62–72)

70 (66–77)

54 (35–67)^c

0.50

< 0.001

Education, y

9 (5–12)

9 (6–12)

14 (10–15)

9 (5–15)

11 (10–14)

0.20

0.47

3 | 1 | 3 | 1 | 26

MMSE, /30

24 (20–26)^d

27 (26–29)

29 (27–30)

23 (19–28)

23 (17–27)

< 0.001

0.99

6 | 1 | 0 | 4 | 26

 Aβ₄₂

578 (486–703)^e

885 (609–1205)

800 (689–1477)

738 (590–1049)

971 (736–1206)

< 0.001

< 0.001

3 | 4 | 4 | 0 | 19

 Aβ_42/40

0.034 (0.027–0.045)^e

0.065 (0.047–0.078)

0.062 (0.051–0 .072)

0.083 (0.055–0.096)

0.086 (0.048–0.097)

< 0.001

< 0.001

33 | 9 | 7 | 12 | 22

 p-tau₁₈₁

82 (66–106)^e

45 (34–60)

41 (39–42)

33 (26–53)

33 (26–42)

< 0.001

< 0.001

3 |4 | 4 | 0 | 19

 t-tau

630 (503–840)^e

276 (229–391)

221 (200–228)

226 (170–388)

220 (144–340)

< 0.001

< 0.001

3 | 4 | 4 | 0 | 19