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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer’s disease

Fig. 2

Source data are available in [7]

Module results. A Heatmap showing relationships between modules and brain imaging outcomes in the basic model (model 1) and final model (model 3). The basic model was adjusted for age, sex, blood clinic location, and APOE genotype, and the final model additionally for BMI, lipid medication use, childhood cognitive ability, educational attainment, and SEP (parental and midlife). Tiles are coloured by effect direction (blue = associated with better outcomes, red = associated with worse outcomes). Effect sizes are presented inside the tiles. Associations significant after multiple testing correction are represented by a solid fill and nominal (p < 0.05) by a fainter fill. Module names in bold were additionally associated with a cognitive outcome in our previous analysis. Data for all models (1-3) are present in Supplementary Table 2. B Table presenting enriched pathways in each module, with the most highly enriched pathways presented first. No pathways were enriched for the tan module.

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