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Table 4 Known activities of CHEMBL1567079 and CHEMBL1370387, nearest neighbour to Anle138b, data retrieved from ChEMBL and PubChem

From: Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b

Compound

Target/process

Activity (μM)

CHEMBL1567097

NPC1 activation

0.50

Increased expression of NF-kB in neuronal cells

0.64

RAB9A activation

0.71

ALOX15 inhibition

12.6

Inhibition of tau fibril formation

20.0

Tau filament binding

Inactive [60]

CHEMBL1370387

RAB9A activation

1.27

NPC1 activation

5.62

ALOX15 inhibition

7.00

Inhibition of tau fibril formation

10.0

Alpha-synuclein inhibition

14.1

SENP6 inhibition

26.5

SENP8 inhibition

29.1

Tau filament binding

Inactive [60]