Compound | Target/process | Activity (μM) |
---|---|---|
CHEMBL1567097 | NPC1 activation | 0.50 |
Increased expression of NF-kB in neuronal cells | 0.64 | |
RAB9A activation | 0.71 | |
ALOX15 inhibition | 12.6 | |
Inhibition of tau fibril formation | 20.0 | |
Tau filament binding | Inactive [60] | |
CHEMBL1370387 | RAB9A activation | 1.27 |
NPC1 activation | 5.62 | |
ALOX15 inhibition | 7.00 | |
Inhibition of tau fibril formation | 10.0 | |
Alpha-synuclein inhibition | 14.1 | |
SENP6 inhibition | 26.5 | |
SENP8 inhibition | 29.1 | |
Tau filament binding | Inactive [60] |