Fig. 4From: Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138bDifferentially expressed genes after 3, 7 and 14 days of treatment (in columns) and for unseeded cells (left) and seeded cells (right). Points are coloured by whether they satisfy the threshold of p ≤ 0.05 and |Log2FC |≥ 1.5 (indicated by dashed lines on each plot). DEGs which appear in the Open Targets Alzheimer Disease or Tauopathies association lists are represented by enlarged points (see Supplementary File 2 for full association score details). Genes of interest are labelled if they are either part of the most differentially expressed genes or part of the Open Targets association lists or bothBack to article page