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Table 3 Results from robust regression testing the relationships of a) HOMA2-IR and diabetic status, as well as b) their interaction with amyloid PET DVR, to tau PET SUVR in the entorhinal cortexa

From: The relationship of insulin resistance and diabetes to tau PET SUVR in middle-aged to older adults

 

HOMA-IR sample

Diabetic Status sample

b (SE)b

p

95% CI

b (SE)b

p

95% CI

(a)

Age (years)

.001 (.002)

.42

−.002 to .005

.004 (.002)

.02

.001 to .007

Sex (0=female)

−.06 (.03)

.04

−.11 to −.003

−.02 (.03)

.56

−.07 to .04

Cognitive status (0=unimpaired)c

.20 (.13)

.13

−.06 to .46

.22 (.09)

.02

.04 to .41

Amyloid PET DVR

.68 (.12)

<.001

.45 to .91

.79 (.10)

<.001

.60 to .99

HOMA2-IR

.02 (.02)

.23

−.01 to .05

--

--

--

Cohort (WRAP=0)

--

--

--

.08 (.03)

.004

.03 to .14

Diabetic status (0=nondiabetic)

--

--

--

.04 (.04)

.32

-.04 to .13

(b)

Age (years)

.001 (.002)

.39

−.002 to .005

.004 (.002)

.04

.0002 to .007

Sex (0=female)

−.06 (.03)

.04

−.11 to −.003

−.03 (.03)

.30

−.08 to .03

Cognitive status (0=unimpaired)c

.19 (.13)

.16

.07 to .45

.23 (.09)

.01

.05 to .41

Amyloid PET DVR (centered)d

.69 (.13)

<.001

.44 to .93

.75 (.11)

<.001

.54 to .97

HOMA2-IR (centered)e

.03 (.03)

.42

−.03 to.09

--

--

--

HOMA2-IR × amyloid PET DVR

.10 (.23)

.68

−.36 to .55

--

--

--

Cohort (WRAP=0)

--

--

--

.08 (.03)

.008

.02 to .13

Diabetic status (0=nondiabetic)

--

--

--

.06 (.05)

.26

-.04 to .16

Diabetic status × amyloid PET DVR

--

--

--

.36 (.26)

.17

−.16 to .88

  1. Abbreviations: CI Confidence interval; DVR Distribution volume ratio, HOMA2-IR Homeostasis model assessment of insulin resistance, PET Positron emission tomography, SE Standard error, SUVR standardized uptake value ratio
  2. aTau PET SUVR was the average value from bilateral entorhinal cortex
  3. bComputed using a heteroscedasticity-consistent standard error estimator (HC3)
  4. cn=9 with MCI in HOMA-IR sample; n=23 with MCI and n=6 with dementia in Diabetic Status sample
  5. dAmyloid PET DVR centered at cut-off for amyloid PET positivity (DVR = 1.19)
  6. eHOMA2-IR centered at mean