From: The relationship of insulin resistance and diabetes to tau PET SUVR in middle-aged to older adults
 | (N=394) | Diabeticb amyloid PET positivec (n=6) | Non-diabetic amyloid PET positivec (n=88) | p | Diabeticb amyloid PET negative (n=31) | Non-diabetic amyloid PET negative (n=269) | p |
---|---|---|---|---|---|---|---|
Age (years) | 68.0 (7.1) | 75.12 (6.4) | 71.3 (5.2) | .09 | 68.7 (7.2) | 66.7 (7.2) | .14 |
Sex (female) | 261 (66.2) | 4 (66.7) | 55 (62.5) | 1.0 | 20 (64.5) | 182 (67.7) | .84 |
Race/ethnic group: | Â | Â | Â | .002 | Â | Â | <.001 |
White | 358 (90.9) | 3 (50.0) | 84 (95.5) | <.001 | 21 (67.7) | 250 (92.9) | <.001 |
Black | 22 (5.6) | 1 (16.7) | 3 (3.4) | >.05 | 8 (25.8) | 10 (3.7) | <.001 |
American Indian, Asian, Hispanic/Spanishd | 14 (3.6) | 2 (33.3) | 1 (1.1) | <.001 | 2 (6.5) | 9 (3.3) | >.05 |
Education (years) | 16.1 (2.4) | 17.3 (2.1) | 16.1 (2.3) | .18 | 15.3 (2.2) | 16.2 (2.4) | .05 |
 | n=272 HOMA2-IR | n=1 | n=66 |  | n=21 | n=184 |  |
HOMA2-IRe | 1.1 (0.7) | 0.5 | 1.0 (0.4) | -- | 1.7 (0.9) | 1.1 (0.7) | <.001 |
 | n=381 Glucose | n=5 | n=85 |  | n=27 | n=264 |  |
Glucose (mg/dL) | 98.5 (14.1) | 117.6 (31.7) | 96.5 (9.1) | .21 | 131.0 (21.8) | 95.5 (8.6) | <.001 |
Prediabetesf | 100 (25.9) | -- | 28 (32.9) | Â | -- | 72 (27.3) | Â |
Diabetic medications: | Â | Â | Â | Â | Â | Â | Â |
 Diabetics | 27 (6.9) | 3 (50.0) | -- |  | 24 (77.4) | -- |  |
 Non-diabeticsg | 4 (1.0) | -- | 0 (0.0) |  | -- | 4 (1.5) |  |
 | n=379 APOE4 allele status | n=5 | n=83 |  | n=28 | n=263 |  |
APOE4 allele status: | Â | Â | Â | Â | Â | Â | .14 |
 Non-carrier | 228 (60.2) | 2 (40.0) | 27 (32.5) | 1.0 | 24 (85.7) | 175 (66.5) |  |
 ε2 ε4 | 9 (2.4) | 0 (0.0) | 1 (1.2) |  | 1 (3.6) | 7 (2.7) |  |
 ε3 ε4 | 120 (31.7) | 2 (40.0) | 40 (48.2) |  | 3 (10.7) | 75 (28.5) |  |
 ε4 ε4 | 22 (5.8) | 1 (20.0) | 15 (8.1) |  | 0 (0.0) | 6 (2.3) |  |
Amyloid PET DVRh | 1.17 (0.23) | 1.62 (.31) | 1.50 (.23) | .25 | 1.06 (.05) | 1.06 (.05) | .72 |
Tau PET SUVR, ECi | 1.12 (0.32) | 1.94 (.53) | 1.37 (.48) | .006 | 1.02 (.15) | 1.03 (.17) | .83 |
Tau PET positivej | 61 (15.5) | 6 (100.0) | 37 (42.0) | .007 | 3 (9.7) | 15 (5.6) | .41 |
Tau PET SUVR, MTLk | 1.00 (.27) | 1.62 (.49) | 1.21 (.40) | .02 | .92 (.11) | .93 (.13) | .52 |
Tau PET SUVR, temporal meta-ROIl | 1.15 (.31) | 1.70 (.44) | 1.37 (.53) | .15 | 1.06 (.11) | 1.08 (.11) | .48 |
Time to tau PETm (years) | .92 (.94) | .96 (.92) | 1.02 (1.05) | .90 | .88 (.67) | .90 (.94) | .89 |
MCIn | 23 (5.8) | 1 (16.7) | 15 (17.0) | 1.0 | 2 (6.5) | 5 (1.9) | .16 |
Dementian | 6 (1.5) | 1 (16.7) | 3 (3.4) | .24 | 1 (3.2) | 1 (0.4) | .20 |