Table 2 Influx and efflux time constants of the AD clusters. p-values of the two-sample t-test performed on the time constants τ_in and τ_out (reported as mean ± sem [min] across animals) for the influx and the efflux of the DOTAREM for the AD clusters. *p < 0.05; ^#trend for statistical significance

p-value (in) = 

0.2868

0.0209*

0.0204*

0.0327*

0.0563^#

0.4011

0.0260*

0.1161

0.1541

0.6050

τ_{in (CTL)} [min]

3.0 ± 1.8

3.5 ± 1.7

4.0 ± 1.9

3.3 ± 1.4

2.5 ± 1.6

9.7 ± 3.0

2.6 ± 1.7

1.6 ± 0.9

0.8 ± 0.1

0.8 ± 0.1

τ_{in (AD)} [min]

9.1 ± 5.1

25.0 ± 7.3

23.6 ± 6.5

19.6 ± 6.2

12.9 ± 4.4

13.8 ± 3.4

21.9 ± 6.9

9.7 ± 4.5

2.7 ± 1.1

0.7 ± 0.1

p-value (out) = 

0.5503

0.7787

0.2947

0.7097

0.4027

0.3415

0.8662

0.2634

0.1631

0.9691

τ_{out (CTL)} [min]

77.3 ± 32.5

54.3 ± 7.0

43.5 ± 8.4

69.6 ± 17.9

60.5 ± 9.5

179.5 ± 20.5

56.8 ± 8.6

55.8 ± 10.1

41.8 ± 6.1

34.3 ± 2.8

τ_{out (AD)} [min]

56.9 ± 3.5

56.4 ± 2.6

53.0 ± 1.2

62.5 ± 3.8

71.9 ± 8.7

132.5 ± 41.8

55.2 ± 3.1

92.0 ± 28.3

92.0 ± 32.2

33.9 ± 8.5