Fig. 3From: The dynamics of plasma biomarkers across the Alzheimer’s continuumAssociations of plasma biomarkers with AD pathologies and discrimination of Aβ status. Associations of plasma biomarkers with AD pathologies were tested using multiple linear regressions adjusted for age and sex. A Associations of plasma levels with CSF AD core biomarkers were tested in CU A−T− and preclinical AD (CU A+T−, CU A+T+) groups (the upper part) and in CU A−T− and prodromal AD (CU A+T−, CU A+T+, and MCI+) groups (the lower part). Colors represent correlation coefficients (β) in regression models and the color bar represents the range of β values obtained. Significance: ***p<0.001, **p<0.01, *p<0.05, −: p≥0.05 (FDR-corrected). B Relationships between plasma levels and cerebral amyloid burden as assessed on Aβ (18F-AV45) PET images. Aβ PET standard uptake value ratios (SUVRs) of different brain regions were extracted beforehand. Plasma GFAP and p-tau181 showed remarkably positive associations with Aβ PET SUVRs in many brain regions among MCI+ and AD dementia patients. Colors represent t values in regression models and the color bar represents the range of t values obtained. C Receiver operating curve analyses to discriminate Aβ-positive from Aβ-negative status. The upper and bottom plots showed the AUCs of different plasma biomarkers (plasma Aβ42/Aβ40, Aβ42, Aβ40, p-tau181, NfL, and GFAP) in discriminating Aβ status defined by CSF Aβ42 and Aβ PET, respectively. Abbreviations: AD, Alzheimer’s disease; Αβ, amyloid-β; CSF, cerebrospinal fluid; MCI, mild cognitive impairment; FDR, false discovery rate; GFAP, glial fibrillary acidic protein; p-tau, phosphorylated tau; PET, positron emission tomography; CU, cognitively unimpaired; NfL, neurofilament light; AUC, area under the curveBack to article page