From: Phenotype and imaging features associated with APP duplications
 | APP duplication with CAA on MRI | CAA comparison group | Crude | After adjustment for onset-MRI delaya | ||
---|---|---|---|---|---|---|
(n = 14) | (n = 40) | OR/CI | p value | OR/CI | p-value | |
Blood-sensitive sequence | ||||||
 - T2* | 13 | 36 |  |  |  |  |
 - SWI or SWAN | 1 | 4 |  |  |  |  |
Age at IRM (years, mean ± SD) | 55.2 ± 6.2 | 68.2 ± 8.5 |  | 9.2 × 10−7 |  |  |
Time from symptom onset to MRI (years, mean ± SD) | 4.1 ± 3.1 | 3.3 ± 3.6 |  | 0.458 |  |  |
Hemorrhages ICH and CSS | ||||||
Presence of ICH | ||||||
 Lobar | 10 (71.4%) | 24 (60.0%) | 1.55 [0.36 ;8.02] | 0.746 | 1.15 [0.20 ; 6.68] | 0.873 |
 Posterior fossa | 2 | 0 | ||||
 Deep | 0 | 0 | ||||
Presence of cortical superficial siderosis | Â | Â | Â | Â | Â | Â |
- At least one sulcus (focal and disseminated) | 2 (14.2%) | 21 (52.5%) | 0.15 [0.01;0.80] | 0.013 | 0.33 [0.04;2.14] | 0.266 |
- Disseminated CSS only | 0 | 15 (37.5%) | 0 [0.00;0.59] | 0.005 | 0.06 [0.00;0.47] | 0.0038 |
Microbleeds | ||||||
 Presence in posterior fossa | 6 (42.8%) | 7 (17.5%) |  | 0.07 |  |  |
 Lobar MBs (mean ± SD) | 110.7 ± 146.6 | 56.7 ± 121.3 | 55.3 [− 146.8; 36.1] | 0.221 | 47.5 [− 56.6; 51.8] | 0.364 |
 Ratio post./ant. | 10.1 ± 12.5 | 5.3 ± 15.2 | 4.5 [− 13.0; 4.0] | 0.291 | 8.1 [− 3.7; 20.0] | 0175 |
 Presence in deep gray matter | 2 (14.2%) | 0 |  |  |  |  |
Infarct | ||||||
 Presence of lacunes | 0 | 5 (12.5%) |  | 0.31 |  |  |
 Presence of large vessel infarcts | 2 (14.2%) | 1 (2.5%) |  | 0.16 |  |  |
WM hyperintensities (Fazekas scale, mean ± SD) | ||||||
 Modified Fazekas score in the pre-rolandic WM regions | 0.9 ± 0.64 | 1.6 ± 0.9 | 0.59 [0.13; 1.04] | 0.013 | − 0.60 [− 1.13; − 0.07] | 0.125 |
 Modified Fazekas score in the post-rolandic WM regions | 1.5 ± 1.0 | 1.9 ± 0.9 | 0.41 [− 0.28; 1.10] | 0.226 | − 0.44 [− 1.08 ; 0.18] | 0.262 |
Hippocampal atrophy (Scheltens scale, mean) | ||||||
 Right | 1.7 ± 1.4 | 1.6 ± 1.3 | 0.1 [− 1.1; 0.8] | 0.780 | 0.10 [− 0.82; 1.02] | 0.503 |
 Left | 2.0 ± 1.5 | 1.7 ± 1.2 | 0.25 [− 1.20; 0.70] | 0.593 | 0.23 − 0.66; 1.13] | 0.065 |