Skip to main content

Table 3 Radiological data compared to CAA controls

From: Phenotype and imaging features associated with APP duplications

 

APP duplication with CAA on MRI

CAA comparison group

Crude

After adjustment for onset-MRI delaya

(n = 14)

(n = 40)

OR/CI

p value

OR/CI

p-value

Blood-sensitive sequence

 - T2*

13

36

    

 - SWI or SWAN

1

4

    

Age at IRM (years, mean ± SD)

55.2 ± 6.2 

68.2 ± 8.5

 

9.2 × 10−7

  

Time from symptom onset to MRI (years, mean ± SD)

4.1 ± 3.1 

3.3 ± 3.6

 

0.458

  

Hemorrhages ICH and CSS

Presence of ICH

 Lobar

10 (71.4%)

24 (60.0%)

1.55 [0.36 ;8.02]

0.746

1.15 [0.20 ; 6.68]

0.873

 Posterior fossa

2

0

 Deep

0

0

Presence of cortical superficial siderosis

      

- At least one sulcus (focal and disseminated)

2 (14.2%)

21 (52.5%)

0.15 [0.01;0.80]

0.013

0.33 [0.04;2.14]

0.266

- Disseminated CSS only

0

15 (37.5%)

0 [0.00;0.59]

0.005

0.06 [0.00;0.47]

0.0038

Microbleeds

 Presence in posterior fossa

6 (42.8%)

7 (17.5%)

 

0.07

  

 Lobar MBs (mean ± SD)

110.7 ± 146.6

56.7 ± 121.3

55.3 [− 146.8; 36.1]

0.221

47.5 [− 56.6; 51.8]

0.364

 Ratio post./ant.

10.1 ± 12.5

5.3 ± 15.2

4.5 [− 13.0; 4.0]

0.291

8.1 [− 3.7; 20.0]

0175

 Presence in deep gray matter

2 (14.2%)

0

    

Infarct

 Presence of lacunes

0

5 (12.5%)

 

0.31

  

 Presence of large vessel infarcts

2 (14.2%)

1 (2.5%)

 

0.16

  

WM hyperintensities (Fazekas scale, mean ± SD)

 Modified Fazekas score in the pre-rolandic WM regions

0.9 ± 0.64

1.6 ± 0.9

0.59 [0.13; 1.04]

0.013

− 0.60 [− 1.13; − 0.07]

0.125

 Modified Fazekas score in the post-rolandic WM regions

1.5 ± 1.0

1.9 ± 0.9

0.41 [− 0.28; 1.10]

0.226

− 0.44 [− 1.08 ; 0.18]

0.262

Hippocampal atrophy (Scheltens scale, mean)

 Right

1.7 ± 1.4

1.6 ± 1.3

0.1 [− 1.1; 0.8]

0.780

0.10 [− 0.82; 1.02]

0.503

 Left

2.0 ± 1.5

1.7 ± 1.2

0.25 [− 1.20; 0.70]

0.593

0.23 − 0.66; 1.13]

0.065

  1. CAA cerebral amyloid angiopathy, ICH intra cerebral hemorrhage, CMB cerebral microbleed, CSS cortical superficial siderosis, WM white matter, CI confidence interval
  2. aLinear (logistic) regressions were performed using each quantitative (resp. binary) variable of interest as output and group as explicative factor with adjustment for time from symptom onset to MRI. The last column gives p-values for the Dup/Non Dup group variable in each regression