Fig. 4From: How does apolipoprotein E genotype influence the relationship between physical activity and Alzheimer’s disease risk? A novel integrative modelAn integrative model of hypothesised associations between apolipoprotein E ε4 carriage, physical activity and Alzheimer’s disease mechanisms. Green lines indicate a positive effect, and red lines indicate a negative effect. Abbreviations: Aβ amyloid-beta, APOE apolipoprotein E, p-tau phosphorylated tau. Created by KS with BioRender.comBack to article page