Table 2 Biomarker data for each cohort, including uncorrected and corrected data (amyloid status as defined by Aβ42/Aβ40 ratio)
CU (A−) | CU (A+) | CU (missing)a | MCI (A−) | MCI (A+) | AD-dementia (all) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Characteristics | ALFA+ | Wisconsin | p | ALFA+ | Wisconsin | p | Wisconsin | Wisconsin | Wisconsin | Wisconsin | Abby/Blaze | p |
N | 263 | 376 | 135 | 160 | 10 | 23 | 33 | 49 | 164 | |||
Uncorrected CSF biomarkers, median (IQR) | ||||||||||||
YKL40, ng/mL | 136.2 (60.6) | 131.8 (58.2) | 0.173 | 147.6 (70.6) | 138.0 (74.9) | 0.548 | 154.8 (64.1) | 152.1 (104.5) | 222.0 (96.8) | 216.4 (129.2) | 191.6 (103.9) | 0.112 |
sTREM2, ng/mL | 7.57 (2.74) | 7.51 (3.15) | 0.163 | 7.58 (3.05) | 7.96 (3.33) | 0.875 | 9.07 (2.59) | 8.11 (2.24) | 9.81 (4.39) | 9.36 (3.74) | 8.93 (4.15) | 0.844 |
GFAP, ng/mL | 7.00 (2.93) | 8.34 (4.30) | <0.001 | 8.02 (3.43) | 8.84 (3.98) | 0.002 | 8.72 (3.75) | 9.02 (5.54) | 14.33 (5.72) | 13.62 (6.24) | 10.58 (6.27) | 0.002 |
IL-6, pg/mL | 3.57 (1.58) | 3.97 (2.01) | <0.001 | 3.52 (1.71) | 3.83 (1.84) | 0.469 | NA | 3.52 (1.38) | 3.33 (1.21) | 4.17 (1.78) | 3.08 (1.52) | <0.001 |
NfL, pg/mL | 75.6 (31.9) | 75.8 (39.5) | 0.481 | 86.2 (36.0) | 90.8 (48.8) | 0.222 | 66.6 (34.7) | 106.6 (116.2) | 151.0 (98.8) | 195.2 (137.4) | 189.6 (82.6) | 0.908 |
Neurogranin, pg/mL | 683.7 (360.7) | 693.4 (353.0) | 0.162 | 805.9 (466.4) | 843.7 (574.5) | 0.914 | 805.7 (439.3) | 666.8 (285.4) | 928.1 (620.2) | 1006.0 (362.9) | 999.9 (757.9) | 0.908 |
S100, ng/mL | 0.97 (0.29) | 1.12 (0.31) | <0.001 | 1.06 (0.38) | 1.12 (0.35) | 0.010 | 0.92 (0.23) | 1.09 (0.35) | 1.30 (0.47) | 1.18 (0.33) | 1.10 (0.32) | 0.038 |
α-Syn, pg/mL | 179.4 (99.6) | 141.7 (74.7) | <0.001 | 190.5 (101.7) | 162.6 (100.6) | <0.001 | 169.6 (71.3) | 142.7 (115.1) | 226.1 (121.0) | 229.2 (134.3) | 379.5 (245.6) | <0.001 |
Aβ40, ng/mL | 16.6 (7.0) | 14.0 (6.0) | <0.001 | 16.9 (6.0) | 13.6 (6.6) | <0.001 | NA | 14.1 (7.0) | 15.1 (6.9) | 13.1 (6.4) | 15.8 (6.7) | 0.007 |
Aβ42, pg/mL | 1417.0 (779.5) | 1029.0 (530.3) | <0.001 | 821.6 (366.0) | 592.9 (315.0) | <0.001 | 431.1 (231.1) | 934.9 (689.7) | 459.9 (214.3) | 401.9 (243.3) | 576.8 (234.5) | <0.001 |
pTau, pg/mL | 13.8 (6.6) | 15.1 (6.5) | 0.013 | 16.8 (10.0) | 20.0 (10.1) | 0.129 | 8.0 (0.0) | 14.6 (6.3) | 27.9 (15.4) | 35.6 (18.9) | 35.5 (23.0) | 0.908 |
tTau, pg/mL | 171.0 (71.1) | 173.1 (74.3) | 0.539 | 209.5 (105.4) | 223.1 (111.4) | 0.639 | 108.1 (28.1) | 175.1 (108.4) | 304.9 (171.5) | 351.7 (135.9) | 345.6 (201.9) | 0.908 |
pTau/Aβ42 | 0.0093 (0.0022) | 0.0150 (0.0049) | <0.001 | 0.0199 (0.0127) | 0.0306 (0.0218) | <0.001 | 0.0400 (0.0000) | 0.0153 (0.0038) | 0.0612 (0.0466) | 0.0860 (0.0565) | 0.0590 (0.0293) | <0.001 |
Aβ42/Aβ40 | 0.0857 (0.0123) | 0.0737 (0.0120) | <0.001 | 0.0523 (0.0188) | 0.0455 (0.0192) | <0.001 | NA | 0.0730 (0.0073) | 0.0303 (0.0083) | 0.0308 (0.0120) | 0.0389 (0.0121) | <0.001 |
Corrected CSF biomarkers, median (IQR) | ||||||||||||
α-Syn, pg/mL | 179.4 (99.6) | 199.3 (105.0) | 0.173 | 190.5 (101.7) | 228.7 (141.4) | 0.025 | 238.5 (100.2) | 200.7 (161.9) | 318.0 (170.2) | 322.3 (188.9) | 379.5 (245.6) | 0.109 |
Aβ40, ng/mL | 16.6 (7.0) | 18.3 (7.8) | 0.094 | 16.9 (6.0) | 17.8 (8.6) | 0.273 | NA | 18.5 (9.1) | 19.7 (9.0) | 17.1 (8.3) | 15.8 (6.7) | 0.250 |
Aβ42, pg/mL | 1417.0 (779.5) | 1670.2 (860.7) | 0.001 | 821.6 (366.0) | 962.3 (511.3) | 0.027 | 699.7 (375.1) | 1517.4 (1119.5) | 746.5 (347.8) | 652.3 (394.9) | 576.8 (234.5) | 0.250 |
pTau/Aβ42 | 0.0093 (0.0022) | 0.0093 (0.0030) | 0.173 | 0.0199 (0.0127) | 0.0188 (0.0135) | 0.453 | 0.0246 (0.0000) | 0.0094 (0.0023) | 0.0377 (0.0287) | 0.0530 (0.0348) | 0.0590 (0.0293) | 0.256 |
Aβ42/Aβ40 | 0.0857 (0.0123) | 0.0916 (0.0149) | <0.001 | 0.0523 (0.0188) | 0.0566 (0.0239) | 0.008 | NA | 0.0907 (0.0091) | 0.0377 (0.0103) | 0.0383 (0.0149) | 0.0389 (0.0121) | 0.908 |