Table 1 Characterization of cohorts (amyloid status as defined by Aβ42/Aβ40 ratio)
CU (A−) | CU (A+) | CU (missing)a | MCI (A−) | MCI (A+) | AD-dementia (all) | ||||
|---|---|---|---|---|---|---|---|---|---|
Characteristics | ALFA+ | Wisconsin | ALFA+ | Wisconsin | Wisconsin | Wisconsin | Wisconsin | Wisconsin | Abby/Blaze |
N | 263 | 376 | 135 | 160 | 10 | 23 | 33 | 49 | 164 |
Age, mean (SD) | 60.5 (4.5) | 60.3 (7.5) | 62.2 (5.0) | 64.0 (7.2) | 60.7 (7.6) | 69.2 (8.5) | 73.7 (7.9) | 72.3 (8.5) | 69.6 (7.8) |
Female, n (%) | 163 (41) | 250 (38) | 81 (20) | 107 (16) | 8 (1) | 12 (2) | 12 (2) | 17 (3) | 85 (52) |
Education, mean (SD) | 13.6 (3.5) | 16.2 (2.5) | 13.3 (3.6) | 16.3 (2.4) | 17.1 (3.1) | 15.7 (2.7) | 16.2 (2.6) | 14.5 (2.7) | NA |
MMSE, mean (SD) | 29.2 (0.9) | 29.4 (0.9) | 29.1 (1.0) | 29.2 (1.0) | 29.3 (1.0) | 28.2 (1.7) | 27.0 (2.2) | 21.7 (3.8) | 21.7 (3.2) |
CDR-SB, mean (SD) | 0 | 0.04 (0.20) | 0 | 0.13 (0.31) | 0 | 1.38 (1.44) | 1.81 (1.18) | 4.44 (1.61) | 4.56 (1.94) |
PACC, mean (SD) | −0.16 (0.93) | −0.13 (1.13) | −0.11 (1.03) | −0.35 (1.29) | −0.02 (0.98) | −2.26 (1.04) | −2.93 (0.97) | −4.60 (1.42) | NA |
APOE-ε4 carriers, n (%) | 111 (28) | 105 (16) | 103 (26) | 86 (13) | 4 (1) | 6 (1) | 20 (3) | 32 (5) | 118 (72) |
APOE-ε4 non-carriers, n (%) | 152 (38) | 251 (39) | 32 (8) | 67 (10) | 6 (1) | 13 (2) | 12 (2) | 16 (3) | 46 (28) |