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Table 3 League table of the changes of overall cognition function: measured with ADAS-Cog

From: The beneficial effect on cognition of noninvasive brain stimulation intervention in patients with dementia: a network meta-analysis of randomized controlled trials

HF-rTMS-F3F4

   

−4.00 (−8.28, 0.28)

 

−0.60 (−6.30, 5.09)

HF-rTMS-F3

0.10 (−7.21, 7.40)

 

*−3.49 (−6.33, −0.65)

 

−0.94 (−5.90, 4.02)

−0.34 (−3.74, 3.06)

HF-rTMS-Mx

 

*−3.03 (−4.43, −1.63)

 

−2.02 (−7.39, 3.35)

−1.42 (−5.49, 2.65)

−1.08 (−4.03, 1.87)

HF-rTMS-F3T3

*−1.98 (−3.54, −0.42)

 

−4.00 (−8.73, 0.73)

*−3.40 (−6.57, −0.23)

*−3.06 (−4.55, −1.57)

−1.98 (−4.53, 0.57)

Sham

−1.10 (−4.04, 1.84)

−5.10 (−11.02, 0.82)

−4.50 (−9.27, 0.27)

*−4.16 (−8.02, −0.30)

−3.08 (−7.46, 1.30)

−1.10 (−4.66, 2.46)

a-tDCS-F3 + c-tDCS-Fp2

  1. Pairwise (upper-right portion) and network (lower-left portion) meta-analysis results are presented as estimate effect sizes for the outcome of changes of cognition function in measurement of ADAS-Cog in patients with Alzheimer’s dementia. Interventions are reported in order of mean ranking of beneficial effect on cognition function in measurement of ADAS-Cog, and outcomes are expressed as mean difference (MD) (95% confidence intervals). For the pairwise meta-analyses, MD of less than 0 indicate that the treatment specified in the row got more beneficial effect than that specified in the column. For the network meta-analysis (NMA), MD of less than 0 indicate that the treatment specified in the column got more beneficial effect than that specified in the row. Bold results marked with * indicate statistical significance
  2. Abbreviations: ADAS-Cog, Alzheimer’s disease assessment scale-cognitive subscale; HF-rTMS-F3F4, high-frequency rTMS over bilateral DLPFC; HF-rTMS-F3, high-frequency rTMS over left DLPFC; HF-rTMS-Mx, high-frequency rTMS multifocal stimulation; HF-rTMS-F3T3, high-frequency rTMS over left DLPFC and left lateral temporal lobe; a-tDCS-F3 + c-tDCS-Fp2, anodal tDCS of the left DLPFC and cathodal over the right supraorbital region; DLPFC, dorsolateral prefrontal cortex; rTMS, repetitive transcranial magnetic stimulation; Sham, sham control; tDCS, transcranial direct current stimulation