Fig. 3

Interaction effects in the Alanine, Aspartate, and Glutamate metabolic pathway. Selected measured metabolites (beige background) and proteins (gray background, bold title) from the alanine, aspartate, and glutamate metabolic pathway are represented by boxplots. Each line of the boxplot is a quartile of the compound abundancy per sample group (relative to the median value of male WT). Boxes are colored blue or orange with triangular or circular points for males and females, respectively. Asterisks above plots denote significant p-values for a sex:genotype interaction effect, less than 0.05 (*) or less than 0.01 (**). M, male; F, female; WT, wild-type; 3xTg-AD, triple transgenic Alzheimer’s disease model