Table 1 Clinical characteristics of probable CAA patients
Total, n = 226 | |
|---|---|
Age (years) | 75.4 ± 7.0 |
Sex (female) | 123 (54.4) |
Education (years) | 10.8 ± 5.3 |
APOE genotype | |
APOE2 carrier | 28 (12.5) |
APOE4 carrier | 98 (43.4) |
Aβ PET positivity | 91/122 (74.6) |
Follow-up period (years) | 3.5 ± 2.7 |
MRI finding | |
Number of lobar CMBs | 5 (2–16) |
Presence of cSS | 62 (27.4) |
Presence of lacunes | 84 (37.2) |
Severe CSO-EPVS | 58 (26.9) |
Presence of lobar ICH | 36 (15.9) |
Severe WMH | 50 (22.1) |
WHM in a multi-spot pattern | 157 (70.4) |
Presence of cortical microinfarcts | 70 (31.0) |
Vascular risk factors | |
Hypertension | 112 (49.6) |
Diabetes | 52 (23.0) |
Hyperlipidemia | 65 (28.8) |
Cardiac disease | 17 (7.5) |
Stroke | 33 (14.6) |
Current smoking | 41 (18.1) |
Anticoagulant use | 4 (1.78) |
Clinical outcome | |
Lobar ICH | 10 (4.4) |
Stroke | 8 (3.5) |
Seizure | 1 (0.4) |
MMSE* | 21.2 ± 6.5 |
CDR-SB | 3.8 ± 3.5 |