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Table 3 The joint association of walking pace (slow vs. average or brisk) and handgrip strength (the first quartile vs. the 2–4 quartiles) with new-onset dementia

From: Walking pace, handgrip strength, age, APOE genotypes, and new-onset dementia: the UK Biobank prospective cohort study

Groupa

N

Events (%)

Crude model

Adjusted model

HR (95%CI)

P value

HR (95%CI)

P value

1

18,722

465 (2.5)

Ref

 

Ref

 

2

21,742

268 (1.2)

0.46 (0.39, 0.53)

 < 0.001

0.68 (0.57, 0.82)

 < 0.001

3

94,171

1182 (1.3)

0.47 (0.42, 0.52)

 < 0.001

0.62 (0.54, 0.72)

 < 0.001

4

361,065

2001 (0.6)

0.19 (0.17, 0.21)

 < 0.001

0.45 (0.40, 0.52)

 < 0.001

  1. Adjusted for age, sex, ethnicities, BMI, socioeconomic deprivation, smoking and alcohol drinking status, education levels, physical activity, healthy diet scores, C-reactive protein (CRP), albumin, cardiovascular disease (CVD), hypertension, depression, diabetes, and family history of dementia
  2. aGroup 1, slow walking pace and grip strength in the first quartile;
  3. Group 2, slow walking pace and grip strength in the 2–4 quartiles;
  4. Group 3, average or brisk walking pace and grip strength in the first quartile;
  5. Group 4, average or brisk walking pace and grip strength in the 2–4 quartiles