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Table 4 Overall mortality risk associated with dementia across the age, sex, and COVID-19 wave and antipsychotics in dementia

From: Dementia and psychotropic medications are associated with significantly higher mortality in geriatric patients hospitalized with COVID-19: data from the StockholmGeroCovid project

Patients with COVID-19—hazard ratios (95% CI)

Strata: age, sex, wave

Dementia vs dementia-free

Interaction: dementia vs. age, sex, wave, antipsychotics

Fully adjusted

 Age groups

Age ≤70

4.47 (1.96–10.2)**

0.82 (0.70–0.97)*

Age 71–80

1.76 (1.28–2.43)*

Age 81–90

1.77 (1.47–2.14)**

Age >90

1.21 (0.97–1.51)

 Sex

Women

1.49 (1.23–1.79)**

1.29 (1.01–1.64)*

Men

1.76 (1.47–2.11)**

 COVID-19 wave

First

1.37 (1.13–1.65)*

1.09 (0.91–1.31)

Second

1.96 (1.61–2.40)**

Third

1.30 (0.86–1.96)

Strata: dementia

Antipsychotics users vs non-users

 

 Dementia

No

1.80 (1.50–2.16)**

0.91 (0.68–1.22)

Yes

1.42 (1.11–1.84)*

  1. The fully adjusted model included age at admission (in sex analyses); sex (in age analyses); comorbidity; oxygen saturation; use of statins; antipsychotic, anxiolytic, and hypnotic/sedative medication; and dementia. The interactions of dementia status with COVID-19 waves and antipsychotic usage were not considered statistically significant on the α level of 0.05; *p-value<0.05; **p-value<0.001