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Table 4 Multivariable linear regression analysis between the PSWEs and various indicators in patients with OSA (n=275)

From: Paroxysmal slow wave events are associated with cognitive impairment in patients with obstructive sleep apnea

 

Total PSWEs

PSWEs at F4/M1 in stage R

PSWEs at O1/M2 in stage R

PSWEs at O2/M1 in stage R

β (SE)

P value

β (SE)

P value

β (SE)

P value

β (SE)

P value

NDE Aβ42

0.106 (0.228)

0.076

0.047 (0.065)

0.440

0.060 (0.075)

0.323

0.063 (0.076)

0.296

WMH volume

0.206 (0.000)

0.001

0.039 (0.000)

0.527

0.089 (0.000)

0.146

0.066 (0.000)

0.281

Total CSVD burden

0.087 (0.144)

0.137

0.031 (0.041)

0.606

0.078 (0.049)

0.189

0.089 (0.050)

0.133

ESS

0.136 (0.034)

0.025

0.076 (0.010)

0.222

0.036 (0.011)

0.558

0.018 (0.011)

0.763

AHI

0.037 (0.007)

0.546

0.076 (0.002)

0.221

0.035 (0.002)

0.564

0.031 (0.002)

0.618

ODI

−0.015 (0.007)

0.809

0.045 (0.002)

0.464

−0.001 (0.002)

0.989

−0.005 (0.002)

0.941

Mean SaO2

−0.351 (0.048)

<0.001

−0.229 (0.014)

<0.001

−0.174 (0.017)

0.004

−0.174 (0.017)

0.004

Min SaO2

−0.069 (0.014)

0.263

−0.105 (0.004)

0.094

−0.008 (0.005)

0.897

−0.011 (0.005)

0.855

T90

0.129 (0.009)

0.031

0.122 (0.003)

0.046

0.089 (0.003)

0.141

0.087 (0.003)

0.151

  1. Abbreviations: PSWE paroxysmal slow wave event, OSA obstructive sleep apnea, SE standard error, Aβ amyloid-β, WMH white matter hyperintensity, CSVD cerebral small vessel disease, ESS Epworth Sleepiness Scale, AHI apnea-hypopnea index, ODI oxygen desaturation index, mean SaO2 mean oxygen saturation during sleep, min SaO2 minimum oxygen saturation during sleep, T90 percentage of time oxygen saturation <90%