Alpha-synuclein: a pathological factor with Aβ and tau and biomarker in Alzheimer’s disease

Table 1 Interaction between α-synuclein and amyloid-beta

Types of ligands	Types of α-syn	Consequences
Aβ	α-syn	Aβ aggregation↑ [41, 42] α-syn aggregation↑ [43, 45]
Aβ monomer	α-syn monomer	Stabilization of α-syn oligomer [44] Aβ fibrilization↓ and Aβ oligomerization↑ [49]
	α-syn oligomer	Stabilization of α-syn oligomer [44]
	α-syn fibril	Aβ fibrilization↑ [49]
Aβ oligomer	α-syn monomer	Aβ fibrilization↓ and Aβ oligomerization↑ [49]
	α-syn oligomer	Stabilization of Aβ cross-β structure [47] Aβ fibrilization↓ and Aβ oligomerization↑ [49]
	α-syn fibril	Aβ fibrilization↑ [49]
Aβ fibril	α-syn monomer	Second nucleation of Aβ↓ [48]
Aβ fibril	α-syn fibril	Second nucleation of Aβ↑ [48, 49]

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