Synergistic interaction of high blood pressure and cerebral beta-amyloid on tau pathology

Table 5 Interaction effects of history of hypertension or current blood pressure with global Aβ on inferior temporal tau deposition

	β (SE)	p-value
IT tau ~ BP marker × global Aβ + BP marker + global Aβ + age + sex + APOE4 + VRS^a
History of hypertension × global Aβ	0.186 (0.152)	0.224
High current SBP state × global Aβ	0.359 (0.141)	0.014
High current DBP state × global Aβ	0.696 (0.158)	< 0.001
Current SBP (continuous) × global Aβ	0.011 (0.004)	0.005
Current DBP (continuous) × global Aβ	0.019 (0.006)	0.002

Abbreviations: Aβ β-amyloid, BP blood pressure, APOE4 apolipoprotein E ε4 positivity, VRS vascular risk score, SBP systolic blood pressure, DBP diastolic blood pressure, SE standard error
^a Summary of generalized linear regression model, repeated for each blood pressure marker (e.g., history of hypertension, high current blood pressure state, or current blood pressure level) and global Aβ as interactive predictors of tau deposition

ISSN: 1758-9193