Clinical performance of an antibody-free assay for plasma Aβ42/Aβ40 to detect early alterations of Alzheimer’s disease in individuals with subjective cognitive decline

Table 2 Performance of logistic regression models in predicting Aβ-PET status

Model	AUC	95% CI	Se	Sp	Acc	PPV	NPV	P value^a
Aβ42/Aβ40	0.87	0.80–0.93	86.1%	80.5%	81.5%	49.2%	96.4%	.1544
Aβ42/Aβ40, age, sex, *APOE*	0.89	0.83–0.94	86.1%	77.4%	79.0%	45.6%	96.2%	.0054
Age, sex, *APOE*	0.81	0.74–0.88	80.6%	69.5%	71.5%	36.7%	94.2%	-

Abbreviations: Acc accuracy, APOE apolipoprotein E, AUC Area under the ROC curve, CI confidence interval, NPV negative predictive value, PPV positive predictive value, Se sensitivity, Sp specificity
P values in bold correspond to statistically significant results
^a P values correspond to the comparison of the AUCs of the Aβ42/Aβ40 model and the full model (Aβ42/Aβ40, age, sex, APOE ɛ4 number of alleles) with the AUC of the model comprising age, sex and APOE ɛ4 number of alleles, using the DeLong test

ISSN: 1758-9193