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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Clinical performance of an antibody-free assay for plasma Aβ42/Aβ40 to detect early alterations of Alzheimer’s disease in individuals with subjective cognitive decline

Fig. 3

Cross-validation in an independent cohort. A Receiver operating characteristic (ROC) curve for discriminating Aβ-PET status in the DPUK-Korean cohort after applying the estimates and intercept of the model established in FACEHBI that included plasma Aβ42/Aβ40, age, sex and APOE ɛ4 number of alleles. B Concordance plot for the model probability scores of the validation model and Aβ-PET dcCL. Black dots correspond to Aβ-PET(−) individuals; red dots correspond to Aβ-PET(+) individuals. Dashed vertical line represents the dcCL cutoff for Aβ-PET positivity of the DPUK-Korean cohort. Dashed horizontal line represents the cutoff for the model probability score based on maximum Youden index derived by ROC analyses in FACEHBI. Concordant classification is represented by the grey area. Abbreviations: APOE, apolipoprotein E; AUC, area under the curve; CI, confidence interval; dcCL: direct comparison centiloid units; PL, plasma

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