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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired individuals

Fig. 4

Tau368/t-tau is associated with cognitive performance in symptomatic AD patients. Associations between cognitive performance as indexed by MoCA score and CSF A tau368/t-tau, B p-tau217, and C p-tau181 and D t-tau. Participants are stratified into Aβ+ MCI and AD dementia vs. all others. AD, Alzheimer's disease; MCI, mild cognitive impairment; CI, cognitive impairment; P-tau181/217, phosphorylated tau 181/217; T-tau, total tau; CSF, cerebrospinal fluid; MoCA, Montreal cognitive assessment. All P-values and R coefficients are derived from Spearman correlations. One clear outlier, shown in grey and labeled NA, was excluded from the statistical analysis but remain in the graph. Tau368/t-tau, p-tau181, T-tau (n = 107), CSF p-tau217 (n = 100)

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