Fig. 3

Tau368/t-tau abnormality is associated with in vivo Braak staging. Trajectories of A tau368/t-tau, B t-tau, and C p-tau217 and D p-tau181 increase with respect to in vivo Braak staging (I–II, III–IV, and V–VI) as indexed by ¹⁸F-MK-6240 PET. Medians are represented by shapes and error bars indicate interquartile range. Z-scores are derived from cognitively unimpaired elderly participants at Braak stage 0. Young individuals are not included in this graph. N = 56, 14, 8, and 14 individuals were classified as being at Braak stages 0, I–II, III–IV, and V–VI, respectively. Discordant cases n = 12 were excluded from this but included in all other analyses in this paper. All P-values are derived from the Kruskal-Wallis test, adjusted for false discovery rate (FDR) using the Benjamini-Hochberg method. *P < 0.05; ** P < 0.01; *** P < 0.001; P < 0.0001