Fig. 2

Tau368/t-tau is associated with neocortical tau load in symptomatic AD patients. Associations between ¹⁸F-MK-6240 PET SUVR in a priori-defined in vivo Braak stages (I–II, III–IV, and V–VI) and CSF A–C tau368/t-tau, D–F p-tau217, and G–I p-tau181 and J–L t-tau. AD, Alzheimer’s disease; CU, cognitively unimpaired; MCI, mild cognitive impairment; CI, cognitive impairment; P-tau181/217, phosphorylated tau 181/217; T-tau, total tau; CSF, cerebrospinal fluid; SUVR, standardized uptake value ratio. All P-values and R coefficients are derived from Spearman correlations. One clear outlier, shown in grey and labeled NA, was excluded from the statistical analysis but remain in the graph. Tau368/t-tau, p-tau181, T-tau (n = 125), CSF p-tau217 (n = 116)