| Women | Men | P-valuea |
---|---|---|---|
Age (years) | 57.0 ± 8.1 | 57.0 ± 8.1 | 0.85 |
APOE4 carrierb | Â | Â | 0.0027 |
 No | 16,3451 (76.1) | 164,287 (76.5) |  |
 Yes | 51,219 (23.9) | 50,383 (23.5) |  |
Education | Â | Â | 0.39 |
 College/university degree | 66,142 (30.8) | 72,277 (33.7) |  |
 Upper secondary | 25,972 (12.1) | 22,704 (10.6) |  |
 Final stage of secondary education | 51,428 (24.0) | 41,114 (19.2) |  |
 Lower secondary | 11,151 (5.2) | 11,728 (5.5) |  |
 First stage of secondary education | 9202 (4.3) | 19,614 (9.1) |  |
 Vocational qualifications | 12,300 (5.7) | 9617 (4.5) |  |
 None of above | 38,475 (17.9) | 37,616 (17.5) |  |
Household income (pounds) | Â | Â | <0.0001 |
 <18,000 | 53,921 (25.1) | 42,798 (19.9) |  |
 18,000–30,999 | 63,354 (29.5) | 55,153 (25.7) |  |
 31,000–51,999 | 54,080 (25.2) | 59,039 (27.5) |  |
 52,000–100,000 | 34,999 (16.3) | 45,899 (21.4) |  |
 >100,000 | 8316 (3.9) | 11,781 (5.5) |  |
Townsend index | −1.49 ± 2.94 | −1.41 ± 3.05 | <0.0001 |
Alcohol consumption | Â | Â | <0.0001 |
 Never | 9871 (4.6) | 3782 (1.8) |  |
 Previous | 7821 (3.6) | 7146 (3.3) |  |
 Current | 196,978 (91.8) | 203,742 (94.9) |  |
Smoking | Â | Â | <0.0001 |
 Never | 125,641 (58.5) | 103,859 (48.4) |  |
 Former | 70,067 (32.6) | 84,483 (39.4) |  |
 Current | 18,962 (8.8) | 26,328 (12.3) |  |
Physical activity (MET-minutes/week) | 2561 ± 2179 | 2795 ± 2712 | <0.0001 |
Diet scorec | 4.20 ± 1.38 | 3.49 ± 1.40 | <0.0001 |
Sleep duration (hours) | 7.19 ± 1.10 | 7.14 ± 1.08 | <0.0001 |
BMI (kg/m2) | 27.04 ± 5.08 | 27.84 ± 4.19 | <0.0001 |
Overall health rating | Â | Â | <0.0001 |
 Excellent | 37,162 (17.3) | 34,003 (15.8) |  |
 Good | 128,906 (60.0) | 120,844 (56.3) |  |
 Fair | 40,750 (19.0) | 48,891 (22.8) |  |
 Poor | 7852 (3.7) | 10,932 (5.1) |  |
Long-standing illness, disability, or infirmity | Â | Â | <0.0001 |
 No | 149,552 (69.7) | 137,645 (64.1) |  |
 Yes | 65,118 (30.3) | 77,025 (35.9) |  |
Multimorbidity risk score | 0.24 ± 0.27 | 0.30 ± 0.32 | <0.0001 |
Trunk fat percentage | 34.13 ± 7.77 | 27.62 ± 6.71 | <0.0001 |
Whole body fat percentage | 36.58 ± 6.87 | 25.28 ± 5.82 | <0.0001 |
HbA1c (mmol/mol) | 13.52 ± 0.93 | 15.00 ± 1.00 | <0.0001 |
Triglycerides (mmol/L) | 1.58 ± 0.83 | 1.97 ± 1.12 | <0.0001 |
HDL-C (mmol/L) | 1.58 ± 0.35 | 1.30 ± 0.30 | <0.0001 |
LDL-C (mmol/L) | 3.63 ± 0.84 | 3.49 ± 0.83 | <0.0001 |