Association of neurofilament light chain with renal function: mechanisms and clinical implications

Table 5 Bivariate and univariate model fitting comparisons under the competing ACE, AE, CE, and E models

Bivariate	Model	ep	− 2LL	df	Δ− 2LL	Δdf	p	AIC
Correlated factors	ACE	11	4980.17	1885				5002.17
	AE	8	4981.28	1888	1.11	3	0.7374	4997.28
	CE	8	5001.96	1888	21.79	3	< 0.001	5017.96
	E	5	5173.55	1891	193.38	6	< 0.001	5183.55
Univariate	Model	ep	− 2LL	df	Δ− 2LL	Δdf	p	AIC
Creatinine	ACE	4	2536.65	932				2544.65
	AE	3	2537.12	933	0.47	1	0.4945	2543.12
	CE	3	2546.23	933	9.58	1	0.0020	2552.23
	E	2	2655.25	934	118.60	2	< 0.001	2659.25
Plasma NfL	ACE	4	2633.55	956				2641.55
	AE	3	2633.62	957	0.07	1	0.7952	2639.62
	CE	3	2645.60	957	12.05	1	< 0.001	2651.60
	E	2	2723.36	958	89.81	2	< 0.001	2723.36

Best fitting model is in bold font
A additive genetic, C common or shared environment, E non-shared environment, ep number of estimated parameters, − 2LL − 2 × log-likelihood, Δ− 2LL change in − 2 × log-likelihood, Δdf change in degrees of freedom, AIC Akaike Information Criteria

ISSN: 1758-9193