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Table 3 Correlations of plasma NfL with brain structural measures in the ADNI and VETSA samples

From: Association of neurofilament light chain with renal function: mechanisms and clinical implications

ADNI—brain structures

Plasma NfL

p value

Plasma NfL adjusted

p value

Hippocampal volume

− 0.21 [− 0.31, − 0.11]

< 0.001

− 0.18 [− 0.28, − 0.07]

< 0.001

Medial temporal lobe volume

− 0.12 [− 0.23, − 0.01]

0.033

− 0.11 [− 0.23, − 0.00]

0.047

Whole brain volume

− 0.22 [− 0.32, − 0.12]

< 0.001

− 0.21 [− 0.30, − 0.11]

< 0.001

VETSA—brain structures

Plasma NfL

p value

Plasma NfL adjusted

p value

Hippocampal volume

− 0.04 [− 0.15, 0.06]

> 0.05

− 0.03 [− 0.14, 0.07]

> 0.05

Medial temporal lobe volume

0.07 [− 0.03, 0.17]

> 0.05

0.05 [− 0.05, 0.15]

> 0.05

Whole brain volume

0.01 [− 0.09, 0.11]

> 0.05

0.02 [− 0.08, 0.11]

> 0.05

  1. Correlations of plasma NfL are shown with and without adjusting for creatinine. Structural measures were adjusted for age, sex when applicable, and intracranial volume