Fig. 3
From: Association of neurofilament light chain with renal function: mechanisms and clinical implications
Conceptual diagram of plasma NfL, CSF NfL, and serum creatinine. A Venn diagram of the associations among plasma NfL, CSF NfL, and serum creatinine. Shared variance between plasma NfL and serum creatinine is independent of the shared variance between plasma NfL and CSF NfL. B Conceptual plot of plasma NfL indexing the same degree of neurodegeneration in groups with good or poor renal function and in groups after controlling for renal function. Renal function affects the level of plasma NfL and therefore how it performs as a stand-alone measure (e.g., when compared to a threshold for abnormality as shown in the green line). However, adjusting for renal function does not alter the slope of association between plasma NfL and another measure of neurodegeneration