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Table 2 Characteristics of participants in dataset 2

From: Proteomic profiling of circulating plasma exosomes reveals novel biomarkers of Alzheimer’s disease

Characteristic

Total sample (n = 114)

Controls (n = 56)

AD (n =58)

P value

Age, mean (SD)

68.7 (6.5)

68.3 (6.6)

69.1 (6.4)

0.50

Education year, mean (SD)

8.9 (2.2)

9.1 (2.3)

8.7 (2.1)

0.94

Women, no. (%)

59 (51.8)

29 (51.8)

30 (51.7)

1.00

APOE ε4 positive (%)

34 (29.8)

10 (17.9)

24 (41.4) *

< 0.001

MMSE score (SD)

24 (5.2)

28.9 (0.7)

19.2 (2.4) *

< 0.001

Aβ42 (pg/ml), mean (SD)

526.6 (215.8)

702.3 (149.5)

357 (105.8) *

< 0.001

P-tau181 (pg/ml), mean (SD)

83.3 (56.1)

46 (24.8)

119.2 (54.4) *

< 0.001

P-tau181/Aβ42, mean (SD)

0.20 (0.16)

0.07 (0.03)

0.33 (0.11) *

< 0.001

T-tau (pg/ml), mean (SD)

496.5 (202.3)

317.2 (84.9)

616.6 (171.4) *

< 0.001

  1. The values of age, education years, and MMSE are shown as mean (standard deviation)
  2. Abbreviations: AD, Alzheimer’s disease; , amyloid β; APOE ε4, apolipoprotein ε4; MMSE, Mini-Mental State Examination; P-tau, phosphorylated tau; SD, standard deviation; T-tau, total tau
  3. *P < 0.05 compared to controls